Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.75 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.75 |
| ▸ | KDM1A | O60341 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 5/20 | 0.57 |
| ▸ | RAD52 | P43351 | 4/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594095 | 0.95 | TOP2A (0.66) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9594311 | 0.93 | TOP2A (0.64) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9595254 | 0.93 | TOP2A (0.75) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9594844 | 0.91 | TOP2A (0.61) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9595077 | 0.90 | TOP2A (0.59) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9595112 | 0.89 | TOP2A (0.59) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9595260 | 0.89 | TOP2A (0.58) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9595379 | 0.89 | TOP2A (0.58) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9594389 | 0.88 | KDM1A (0.69) | TOP2ATOP2BKDM1AKMT2APOLB | |
| SCHEMBL9594471 | 0.88 | TOP2A (0.66) | TOP2ATOP2BKDM1AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |