Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.66 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.66 |
| ▸ | KDM1A | O60341 | 4/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | TERT | O14746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594311 | 0.95 | TOP2A (0.64) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9595254 | 0.95 | TOP2A (0.75) | TOP2ATOP2BKDM1ACYP19A1KMT2A | |
| SCHEMBL9595513 | 0.94 | TOP2A (0.59) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9593418 | 0.93 | TOP2A (0.58) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9595086 | 0.93 | TOP2A (0.58) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9594934 | 0.91 | TOP2A (0.59) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9592813 | 0.90 | TOP2A (0.55) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9593532 | 0.90 | TOP2A (0.55) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9594095 | 0.90 | TOP2A (0.66) | TOP2ATOP2BKDM1ACYP19A1TERT | |
| SCHEMBL9595112 | 0.89 | TOP2A (0.59) | TOP2ATOP2BKDM1ACYP19A1TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |