Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.57 |
| ▸ | KDM1A | O60341 | 5/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595076 | 0.96 | HDAC1 (0.55) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9594991 | 0.94 | KDM1A (0.54) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9595701 | 0.94 | KDM1A (0.54) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9594305 | 0.93 | PHLPP2 (0.61) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9594191 | 0.91 | KDM1A (0.59) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9595042 | 0.90 | KDM1A (0.55) | KDM1A | |
| SCHEMBL9595381 | 0.89 | HDAC1 (0.54) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9594489 | 0.88 | KDM1A (0.59) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9594934 | 0.88 | TOP2A (0.59) | HDAC1HDAC6PHLPP2KDM1AADORA2A | |
| SCHEMBL9594504 | 0.87 | KDM1A (0.69) | HDAC1HDAC6PHLPP2KDM1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |