Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.58 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595260 | 0.94 | TOP2A (0.58) | TOP2ATOP2BCYP19A1KDM1APDPK1 | |
| SCHEMBL9594471 | 0.93 | TOP2A (0.66) | TOP2ATOP2BCYP19A1KDM1APHLPP2 | |
| SCHEMBL9592813 | 0.93 | TOP2A (0.55) | TOP2ATOP2BCYP19A1KDM1APDPK1 | |
| SCHEMBL9593532 | 0.93 | TOP2A (0.55) | TOP2ATOP2BCYP19A1KDM1APDPK1 | |
| SCHEMBL9595683 | 0.92 | TOP2A (0.64) | TOP2ATOP2BPDPK1RETKDR | |
| SCHEMBL9594311 | 0.91 | TOP2A (0.64) | TOP2ATOP2BCYP19A1KDM1APHLPP2 | |
| SCHEMBL9594080 | 0.89 | TOP2A (0.58) | TOP2ATOP2BKDM1APDPK1RET | |
| SCHEMBL9593418 | 0.89 | TOP2A (0.58) | TOP2ATOP2BCYP19A1KDM1APHLPP2 | |
| SCHEMBL9595254 | 0.89 | TOP2A (0.75) | TOP2ATOP2BCYP19A1KDM1APHLPP2 | |
| SCHEMBL9595513 | 0.88 | TOP2A (0.59) | TOP2ATOP2BCYP19A1KDM1APHLPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |