Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592981 | 0.96 | KDM1A (0.47) | KDM1AACHEHDAC1HDAC6SLC2A1 | |
| SCHEMBL9592705 | 0.93 | MEN1 (0.46) | KDM1AACHEHDAC1HDAC6SLC2A1 | |
| SCHEMBL9594500 | 0.93 | KDM1A (0.49) | KDM1AACHEHDAC1HDAC6SLC2A1 | |
| SCHEMBL9593806 | 0.91 | KDM1A (0.54) | KDM1ASLC2A1EGFRERBB2DHFR | |
| SCHEMBL9594205 | 0.91 | KDM1A (0.48) | KDM1AHDAC1HDAC6SLC2A1EGFR | |
| SCHEMBL9594922 | 0.90 | KDM1A (0.50) | KDM1AACHEHDAC1HDAC6PHLPP2 | |
| SCHEMBL9594919 | 0.89 | MEN1 (0.46) | KDM1AACHEHDAC1HDAC6SLC2A1 | |
| SCHEMBL9595558 | 0.89 | KDM1A (0.48) | KDM1AHDAC1HDAC6SLC2A1EGFR | |
| SCHEMBL9594966 | 0.89 | KDM1A (0.54) | KDM1ASLC2A1EGFRERBB2POLB | |
| SCHEMBL9595398 | 0.88 | KDM1A (0.51) | KDM1AACHETOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |