Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | RAD52 | P43351 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594205 | 0.98 | KDM1A (0.48) | KDM1ADHFRPDPK1POLBRAD52 | |
| SCHEMBL9594474 | 0.95 | KDM1A (0.51) | KDM1ADHFRPDPK1POLBRAD52 | |
| SCHEMBL9593806 | 0.95 | KDM1A (0.54) | KDM1ADHFRPDPK1POLBRAD52 | |
| SCHEMBL9594966 | 0.95 | KDM1A (0.54) | KDM1APDPK1POLBRAD52MAPT | |
| SCHEMBL9592981 | 0.91 | KDM1A (0.47) | KDM1APOLBRAD52HDAC1HDAC6 | |
| SCHEMBL9594919 | 0.91 | MEN1 (0.46) | KDM1APOLBRAD52HDAC1HDAC6 | |
| SCHEMBL9594286 | 0.90 | HDAC1 (0.52) | KDM1APOLBRAD52MAPTHDAC1 | |
| SCHEMBL9592115 | 0.90 | KDM1A (0.50) | KDM1APOLBRAD52MAPTTP53 | |
| SCHEMBL9593869 | 0.90 | KDM1A (0.54) | KDM1APOLBRAD52MAPTHDAC1 | |
| SCHEMBL9593647 | 0.89 | KDM1A (0.50) | KDM1APDPK1POLBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |