Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.64 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 10/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594484 | 0.94 | TOP2A (0.57) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9593668 | 0.94 | TOP2A (0.57) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9593866 | 0.94 | TOP2A (0.57) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9595086 | 0.92 | TOP2A (0.58) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9595752 | 0.92 | TOP2A (0.58) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9595260 | 0.92 | TOP2A (0.58) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9594080 | 0.92 | TOP2A (0.58) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9593497 | 0.89 | TOP2A (0.57) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9593549 | 0.89 | TOP2A (0.57) | TOP2ATOP2BPDPK1EGFRERBB2 | |
| SCHEMBL9594388 | 0.85 | TOP2A (0.56) | TOP2ATOP2BPDPK1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |