Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597357 | 0.96 | TP53 (0.65) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL9598599 | 0.94 | TP53 (0.63) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL9597872 | 0.91 | MAPT (0.64) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL31485758 | 0.89 | GAA (0.68) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL25121233 | 0.89 | LMNA (0.75) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL13337768 | 0.86 | KDM4E (0.64) | POLBTSHRSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29205452 | 0.85 | TLR8 (0.64) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL9570117 | 0.85 | GAA (0.64) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL30282098 | 0.85 | TLR8 (0.64) | POLBTSHRGAAHTTSMN1; SMN2 | |
| SCHEMBL2361056 | 0.85 | TP53 (0.69) | POLBGAAHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |