SCHEMBL9601157

SCHEMBL9601157

COC(=O)c1c(C)nn(-c2ccccn2)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 9/20 0.50
KMT2A Q03164 2/20 0.46
CASP3 P42574 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ALDH1A1 P00352 5/20 0.45
MAPT P10636 4/20 0.45
KDM4E B2RXH2 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
THRB P10828 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
ALOX15 P16050 1/20 0.43
HSD17B10 Q99714 1/20 0.43
RAB9A P51151 1/20 0.43
GAA P10253 2/20 0.43
RXFP1 Q9HBX9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10561209 0.87 PDE4B (0.56) HPGDKMT2ACASP3SENP8SENP7
SCHEMBL9600693 0.85 HPGD (0.51) HPGDKMT2ATDP1ALDH1A1MAPT
SCHEMBL9599999 0.84 HPGD (0.67) HPGDALDH1A1MAPTKDM4ECYP1A2
SCHEMBL27939024 0.81 HPGD (0.70) HPGDKMT2ACASP3SENP8SENP7
SCHEMBL9602910 0.80 HPGD (0.49) HPGDALDH1A1MAPTKDM4ECYP1A2
SCHEMBL9601990 0.76 NPC1 (0.55) HPGDTDP1ALDH1A1MAPTKDM4E
SCHEMBL123446 0.74 PDE4D (0.67) HPGDKMT2AALDH1A1MAPTKDM4E
SCHEMBL27780413 0.73 ALDH1A1 (0.51) HPGDKMT2ATDP1ALDH1A1MAPT
SCHEMBL10562470 0.73 ALDH1A1 (0.56) HPGDKMT2AALDH1A1MAPTKDM4E
SCHEMBL10514628 0.73 ALDH1A1 (0.48) HPGDALDH1A1MAPTKDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0318602-B1 PYRAZOLESULFONAMIDE DERIVATIVE, PROCESS FOR ITS PRODUCTION AND HERBICIDE CONTAINING IT NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1993-04-28 EP disclosed
US-4881965-A CONTROLLING WILD OATS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1989-11-21 US disclosed