Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10988006 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1BACE1HSD17B10GABRA5 | |
| SCHEMBL9601297 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2NOS1BACE1HSD17B10GABRA5 | |
| SCHEMBL12877376 | 0.79 | NOS1 (0.41) | SMN1; SMN2NOS1BACE1HSD17B10GABRA5 | |
| SCHEMBL190635 | 0.77 | — | — | |
| Bromide SCHEMBL5908220 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2NOS1BACE1HSD17B10ALDH1A1 | |
| SCHEMBL27677871 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1BACE1HSD17B10GABRA5 | |
| SCHEMBL14433411 | 0.74 | BACE1 (0.59) | SMN1; SMN2NOS1BACE1HSD17B10ALDH1A1 | |
| SCHEMBL14433410 | 0.74 | BACE1 (0.59) | SMN1; SMN2NOS1BACE1HSD17B10ALDH1A1 | |
| SCHEMBL965758 | 0.74 | — | — | |
| SCHEMBL12862676 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2NOS1BACE1HSD17B10GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232623-B1 | 1-CARBACEPHALOSPORIN ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4892942-A | 1-CARBA (DETHIA)CEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1990-01-09 | — | — | US | disclosed |
| US-4791106-A | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1988-12-13 | — | — | US | disclosed |
| EP-0232623-A1 | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1987-08-19 | — | — | EP | disclosed |