Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29354440 | 0.71 | SMN1; SMN2 (0.39) | DAOSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL4510784 | 0.71 | SMN1; SMN2 (0.39) | DAOSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7854645 | 0.70 | CA12 (0.40) | CLK4MAPK8DYRK1ADYRK1BDAO | |
| SCHEMBL7740296 | 0.67 | DAO (0.34) | CLK4MAPK8DYRK1ADYRK1BCHEK1 | |
| SCHEMBL9601750 | 0.67 | KDM4E (0.46) | CLK4MAPK8DYRK1ADYRK1BDAO | |
| SCHEMBL7613241 | 0.66 | KDM4E (0.43) | DAOKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL1602164 | 0.66 | CHEK1 (0.54) | CHEK1SMN1; SMN2L3MBTL1PBRM1PDE3B | |
| SCHEMBL29881244 | 0.62 | NPSR1 (0.47) | DYRK1AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8229991 | 0.62 | CA12 (0.52) | DAOSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL30692889 | 0.62 | CA12 (0.52) | DAOSMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012113-A1 | 3-SUBSTITUTED IMIDAZO (1,5-a) AND IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY | THE UPJOHN COMPANY (US) | 1993-06-24 | — | — | WO | disclosed |