Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 7/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602318 | 0.80 | CHRM3 (0.58) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL9602854 | 0.80 | CHRNA7 (0.50) | CHRM3CHRM2CHRM1CHRNA7 | |
| SCHEMBL3743481 | 0.75 | CHRM2 (0.71) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL21095684 | 0.72 | CHRM3 (0.61) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2360215 | 0.72 | CHRM3 (0.61) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2360214 | 0.72 | CHRM3 (0.61) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL1724185 | 0.72 | CHRNA7 (0.62) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL228144 | 0.72 | CHRM3 (0.60) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL228145 | 0.72 | CHRM3 (0.60) | CHRM3CHRM2CHRM1CHRNA7BCHE | |
| SCHEMBL21798510 | 0.71 | NOTUM (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247266-B1 | INDOLE DERIVATIVES HAVING AN AZABICYCLIC SIDE CHAIN, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, AND PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1993-03-10 | — | — | EP | claimed |