Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064192 | 0.76 | POLB (0.57) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL4784582 | 0.74 | ALDH1A1 (0.51) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL4733727 | 0.74 | MAPT (0.55) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL14088821 | 0.72 | POLB (0.66) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL2668504 | 0.70 | ALDH1A1 (0.44) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL6942086 | 0.65 | TP53 (0.34) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL3866807 | 0.60 | PARP1 (0.42) | MAPTLMNAGFERALDH1A1HTT | |
| SCHEMBL4064517 | 0.60 | MAPT (0.43) | MAPTLMNAALDH1A1HTTL3MBTL1 | |
| SCHEMBL5064766 | 0.60 | TP53 (0.43) | LMNAALDH1A1CYP1A2 | |
| SCHEMBL23264535 | 0.60 | ALDH1A1 (0.38) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225182-B1 | CEPHALOSPORIN COMPOUNDS | ICI PHARMA (FR) | 1993-02-10 | — | — | EP | disclosed |
| US-5013731-A | Bactericides | ICI PHARMA (FR) | 1991-05-07 | — | — | US | disclosed |
| EP-0225182-A2 | Cephalosporin compounds | ICI PHARMA (FR) | 1987-06-10 | — | — | EP | disclosed |