Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imiquimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 known ✓ | Q9NYK1 | 14/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | HRH2 | P25021 | 1/20 | 0.82 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 1/20 | 0.82 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.82 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.82 |
| ▸ | HTR2B | P41595 | 1/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.82 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imiquimod SCHEMBL570774 | 0.91 | TLR7 (1.00) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL26136 | 0.91 | TLR7 (1.00) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL29357252 | 0.91 | TLR7 (1.00) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL5262205 | 0.90 | TLR7 (0.88) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL29029396 | 0.90 | TLR7 (0.93) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL1301796 | 0.90 | TLR7 (0.97) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL17962753 | 0.90 | TLR7 (0.97) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL3191041 | 0.89 | TLR7 (0.86) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL3415170 | 0.88 | TLR7 (0.84) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL9602834 | 0.87 | TLR7 (0.82) | TLR7PDE4DLMNAPOLBHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310950-B1 | Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes | RIKER LABORATORIES, INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| EP-0145340-B1 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1990-01-24 | — | — | EP | disclosed |
| EP-0310950-A1 | Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes | RIKER LABORATORIES, INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| US-4689338-A | 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use | RIKER LABORATORIES, INC. (US) | 1987-08-25 | — | — | US | disclosed |
| EP-0145340-A2 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1985-06-19 | — | — | EP | disclosed |