Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 2/20 | 0.44 |
| ▸ | PPM1B | O75688 | 2/20 | 0.44 |
| ▸ | PPP1CC | P36873 | 2/20 | 0.44 |
| ▸ | TFPI2 | P48307 | 2/20 | 0.44 |
| ▸ | PPP5C | P53041 | 2/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | THPO | P40225 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21987140 | 0.88 | TP53 (0.48) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9601537 | 0.88 | TP53 (0.48) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6230684 | 0.72 | — | — | |
| SCHEMBL336246 | 0.71 | KDM4E (0.42) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4968628 | 0.71 | KDM4E (0.42) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL32690600 | 0.71 | KDM4E (0.42) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4464324 | 0.71 | KDM4E (0.42) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5525143 | 0.71 | KDM4E (0.42) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL18923859 | 0.71 | KDM4E (0.42) | TP53LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL24453673 | 0.69 | KDM4E (0.40) | TP53LMNARAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309544-B1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-10 | — | — | EP | disclosed |
| EP-0309544-A1 | PSYCHOTROPIC BICYCLIC IMIDES. | AMERICAN HOME PROD (US) | 1989-04-05 | — | — | EP | disclosed |
| WO-1988007530-A1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | disclosed |
| US-4748240-A | Psychotropic bicyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |