SCHEMBL9602267

SCHEMBL9602267

CC(C[O])Sc1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.49
CYP2C9 P11712 3/20 0.47
CYP2C19 P33261 3/20 0.47
HSD17B10 Q99714 2/20 0.47
MMP2 P08253 1/20 0.46
MMP8 P22894 1/20 0.46
MMP14 P50281 1/20 0.46
HPGD P15428 4/20 0.44
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2D6 P10635 2/20 0.43
MMP1 P03956 1/20 0.42
ALDH1A1 P00352 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
SDCBP O00560 2/20 0.37
SDC2 P34741 2/20 0.37
NPSR1 Q6W5P4 3/20 0.37
MAPT P10636 3/20 0.37
LMNA P02545 2/20 0.37
THRB P10828 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10144008 0.81 TSHR (0.50) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL9602276 0.79 TSHR (0.49) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL7123357 0.76 HSD17B10 (0.52) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL216701 0.75 HSD17B10 (0.50) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL315823 0.73 HSD17B10 (0.48) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL15241839 0.71 CYP2C9 (0.47) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL11290654 0.71 TSHR (0.46) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL28562536 0.71 SMN1; SMN2 (0.51) TSHRCYP2C9CYP2C19HSD17B10HPGD
SCHEMBL11292783 0.71 HSD17B10 (0.47) TSHRCYP2C9CYP2C19HSD17B10MMP2
SCHEMBL11539892 0.71 TSHR (0.42) TSHRCYP2C9CYP2C19HSD17B10MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0232623-B1 1-CARBACEPHALOSPORIN ANTIBIOTICS ELI LILLY AND COMPANY (US) 1993-03-17 EP disclosed
US-4892942-A 1-CARBA (DETHIA)CEPHALOSPORINS ELI LILLY AND COMPANY (US) 1990-01-09 US disclosed
US-4791106-A 1-Carbacephalosporin antibiotics ELI LILLY AND COMPANY (US) 1988-12-13 US disclosed
EP-0232623-A1 1-Carbacephalosporin antibiotics ELI LILLY AND COMPANY (US) 1987-08-19 EP disclosed