SCHEMBL11539892

SCHEMBL11539892

CC(CO)Sc1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.42
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
HSD17B10 Q99714 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
MMP2 P08253 3/20 0.39
MMP8 P22894 2/20 0.39
MMP14 P50281 2/20 0.39
HPGD P15428 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
TRPA1 O75762 1/20 0.37
ALDH1A1 P00352 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MMP9 P14780 2/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9602276 0.89 TSHR (0.49) TSHRHSD17B10CYP2C9CYP2C19MMP2
SCHEMBL11542969 0.81 KDM4E (0.41) TSHRHSD17B10CYP2C9CYP2C19MMP2
SCHEMBL11542967 0.79 TSHR (0.40) TSHRMAOAMAOBHSD17B10CYP2C9
SCHEMBL11537618 0.79 MAOA (0.45) TSHRMAOAMAOBHSD17B10CYP2C9
SCHEMBL11543843 0.78 MAOA (0.41) TSHRMAOAMAOBHSD17B10CYP2C9
SCHEMBL11538958 0.76 MAOA (0.42) TSHRMAOAMAOBHSD17B10CYP2C9
SCHEMBL11538173 0.75 HSD17B10 (0.54) TSHRHSD17B10CYP2C9CYP2C19HPGD
SCHEMBL11464422 0.74 SIGMAR1 (0.48) MAOAMAOB
Glycerin SCHEMBL3228606 0.72 MAOA (0.50) MAOAMAOBMMP2MMP8MMP14
SCHEMBL10144008 0.72 TSHR (0.50) TSHRHSD17B10CYP2C9CYP2C19MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4156011-A TREATMENT OF CARDIOVASCULAR DISORDERS SOCIETE ANONYME DITE: LABORATOIRE L. LAFON (FR) 1979-05-22 US disclosed