Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.54 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637521 | 0.81 | CYP2A6 (0.59) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL19760753 | 0.81 | CYP2A6 (0.59) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL20912808 | 0.81 | CYP2A6 (0.59) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL30905568 | 0.81 | CYP2A6 (0.59) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL3459782 | 0.81 | CYP2A6 (0.59) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL5962350 | 0.81 | CYP2A6 (0.58) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL5540703 | 0.78 | CYP2A6 (0.55) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL9602503 | 0.74 | CYP2A6 (0.54) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL13760611 | 0.73 | AGXT (0.62) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL7031640 | 0.73 | AGXT (0.49) | AGXTCYP2A6ASIC3LOXL2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279263-B1 | INDOLE, BENZOFURAN, BENZOTHIOPHENE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-04 | — | — | EP | disclosed |
| US-4873259-A | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0279263-A2 | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |