Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.73 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.73 |
| ▸ | SHBG | P04278 | 3/20 | 0.73 |
| ▸ | PGR | P06401 | 3/20 | 0.73 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.73 |
| ▸ | AR | P10275 | 3/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.73 |
| ▸ | SNCA | P37840 | 3/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.73 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.73 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | STS | P08842 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960251 | 1.00 | ESR1 (0.73) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL2001122 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL223196 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL7004654 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL13123063 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL23743979 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL223226 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Epiestriol SCHEMBL221084 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL4896486 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG | |
| Estriol SCHEMBL14373308 | 0.85 | ESR1 (1.00) | ESR1ESR2LMNAHIF1ASHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435973-B2 | 17-beta HSD1 and STS inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| CN-102796160-A | 17ss-hsd1 and sts inhibitors | SOLVAY PHARM GMBH | 2012-11-28 | — | — | CN | disclosed |
| CN-101189251-B | 17 beta-HSD 1 and STS inhibitors | SOLVAY PHARM BV | 2012-09-12 | — | — | CN | disclosed |
| EP-1888615-B1 | 17 -HSD1 AND STS INHIBITORS | ABBOTT PRODUCTS GMBH (DE) | 2012-05-16 | — | — | EP | disclosed |
| US-8030298-B2 | 17β-HSD1 and STS inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2011-10-04 | — | — | US | disclosed |
| US-20110021480-A1 | 17-beta HSD1 and STS Inhibitors | SOLVAY PHARMACEUTICALS GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| CN-101189251-A | 17 beta-HSD 1 and STS inhibitors | SOLVAY PHARM GMBH (DE) | 2008-05-28 | — | — | CN | disclosed |
| EP-1888615-A1 | 17 -HSD1 AND STS INHIBITORS | Solvay Pharmaceuticals GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| US-20060281710-A1 | 17SS-HSD1 and STS inhibitors | SOLVAY PHARMACEUTICALS GMBH | 2006-12-14 | — | — | US | disclosed |
| WO-2006125800-A1 | 17β-HSD1 AND STS INHIBITORS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281710-A1 | 17SS-HSD1 and STS inhibitors | HSD17B11, HSD17B1, STS | ESR1 88/4885ESR2 72/4885LMNA 3667/4885 |
| US-20110021480-A1 | 17-beta HSD1 and STS Inhibitors | STS, HSD17B11, HSD17B1 | ESR1 206/4885ESR2 110/4885LMNA 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.