Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591772 | 0.91 | AGTR1 (0.45) | — | |
| SCHEMBL9592176 | 0.90 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9593854 | 0.89 | AGTR1 (0.43) | — | |
| SCHEMBL9592046 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9592404 | 0.86 | NPC1 (0.45) | — | |
| SCHEMBL9590365 | 0.85 | AGTR1 (0.51) | — | |
| SCHEMBL9591064 | 0.83 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9590852 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9591861 | 0.82 | AGTR1 (0.44) | — | |
| SCHEMBL9590973 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5264439-A | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1993-11-23 | — | — | US | disclosed |
| WO-1993009098-A1 | NOVEL 4-CINNOLINONE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 1993-05-13 | — | — | WO | disclosed |