Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746127 | 0.81 | TSHR (0.50) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL19759415 | 0.74 | KDM4E (0.50) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL754946 | 0.71 | ADORA1 (0.51) | ALDH1A1TSHRPPARGNCOA2NCOA1 | |
| SCHEMBL15730603 | 0.71 | ALDH1A1 (0.54) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL10297563 | 0.70 | ADORA1 (0.39) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL17873913 | 0.69 | ALDH1A1 (0.53) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL30461799 | 0.69 | KDM4E (0.53) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL666503 | 0.69 | KDM4E (0.53) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL6877790 | 0.69 | KDM4E (0.53) | ALDH1A1KDM4EGLAGAATSHR | |
| SCHEMBL10747290 | 0.69 | CYP1A2 (0.47) | ALDH1A1KDM4EGLAGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653077-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2014-02-18 | — | — | US | disclosed |
| US-20120135994-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135994-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | ALDH1A1 4628/4885KDM4E 2571/4885GLA 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.