Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14129986 | 0.77 | CYP2D6 (1.00) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL194561 | 0.77 | PSEN1 (0.49) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL27985278 | 0.77 | CYP1A2 (0.65) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL7809444 | 0.75 | CYP3A4 (0.60) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL1983658 | 0.73 | TSHR (0.32) | CYP2D6CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL10280811 | 0.73 | CYP1A2 (0.61) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL14481327 | 0.72 | CYP3A4 (0.42) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL2285981 | 0.71 | CYP1A2 (0.59) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL194670 | 0.71 | CYP1A2 (0.40) | CYP3A4CYP2D6CYP2C9CYP1A2CYP19A1 | |
| SCHEMBL1452840 | 0.69 | HTT (0.38) | CYP3A4CYP2C9CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450343-B2 | Gamma secretase modulators | SCHERING CORPORATION | 2013-05-28 | — | — | US | disclosed |
| US-20110015190-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-01-20 | — | — | US | disclosed |
| EP-2229381-A1 | GAMMA SECRETASE MODULATORS | Schering Corporation (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009073777-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015190-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | CYP3A4 3415/4885CYP2D6 4293/4885CYP2C9 4163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.