Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.62 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.62 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.62 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.62 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.62 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.62 |
| ▸ | PGR | P06401 | 6/20 | 0.60 |
| ▸ | ACLY | P53396 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL97999 | 0.85 | PGR (0.73) | PGR | |
| SCHEMBL29561444 | 0.84 | CES1 (0.81) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL96121 | 0.84 | CES1 (0.81) | PGRCES1 | |
| SCHEMBL6275068 | 0.82 | CYP3A4 (0.62) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL29118844 | 0.82 | PRMT1 (0.66) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL3762452 | 0.81 | PGR (0.74) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL29562342 | 0.81 | PGR (0.72) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL95190 | 0.79 | MAPT (0.62) | CYP3A4CYP2D6PGRCES1 | |
| SCHEMBL29561437 | 0.79 | PGR (0.69) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL29561923 | 0.79 | CA1 (0.63) | CYP3A4CYP2D6PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362252-B2 | Carbostyril compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-29 | — | — | US | disclosed |
| EP-1797082-B1 | CARBOSTYRIL COMPOUND | OTSUKA PHARMA CO LTD (JP) | 2012-08-29 | — | — | EP | disclosed |
| EP-2426128-A1 | Carbostyril compound | Otsuka Pharmaceutical Co., Limited (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20100261705-A1 | CARBOSTYRIL COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. | 2010-10-14 | — | — | US | disclosed |
| US-7777038-B2 | Carbostyril compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-08-17 | — | — | US | disclosed |
| US-20090326008-A1 | NF-kappa B Inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-31 | — | — | US | disclosed |
| EP-2043644-A1 | NF- B INHIBITOR | Otsuka Pharmaceutical Co., Ltd. (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010601-A1 | NF- ϰB INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-24 | — | — | WO | disclosed |
| US-20070179173-A1 | Carbostyril compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-02 | — | — | US | disclosed |
| EP-1797082-A1 | CARBOSTYRIL COMPOUND | Otsuka Pharmaceutical Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006035954-A1 | CARBOSTYRIL COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326008-A1 | NF-kappa B Inhibitor | NFKBIA, NFKB2, IKBKB | CYP3A4 3412/4885CYP2D6 3834/4885PSEN1 3209/4885 |
| US-20070179173-A1 | Carbostyril compound | GTF2F1, F3, GTF2F2 | CYP3A4 953/4885CYP2D6 1754/4885PSEN1 4458/4885 |
| US-20100261705-A1 | CARBOSTYRIL COMPOUND | GTF2F1, F3, GTF2F2 | CYP3A4 953/4885CYP2D6 1754/4885PSEN1 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.