Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.52 |
| ▸ | TNF | P01375 | 5/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982048 | 0.81 | KDR (0.61) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL4439008 | 0.76 | KDR (0.80) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL14122641 | 0.75 | CARM1 (0.60) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL14147238 | 0.72 | KDR (0.53) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL9605547 | 0.71 | KDR (0.70) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL14134955 | 0.70 | NOD1 (0.53) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL9605535 | 0.69 | KDR (1.00) | KDRABCB1ABCG2 | |
| SCHEMBL4979852 | 0.69 | KDR (0.64) | KDRNOD1TNFNOD2CARM1 | |
| SCHEMBL14122438 | 0.68 | KDR (0.82) | KDRCARM1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL9605558 | 0.68 | KDR (0.53) | KDRNOD1CARM1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118088-B1 | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer | AMGEN INC (US) | 2012-05-30 | — | — | EP | disclosed |