Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287061 | 0.89 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3287064 | 0.89 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2575460 | 0.87 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2575459 | 0.87 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3287214 | 0.81 | P2RX7 (1.00) | P2RX7KMT2A | |
| SCHEMBL3287218 | 0.81 | P2RX7 (1.00) | P2RX7KMT2A | |
| SCHEMBL2578506 | 0.80 | P2RX7 (1.00) | P2RX7KMT2A | |
| SCHEMBL3287224 | 0.80 | P2RX7 (1.00) | P2RX7KMT2A | |
| SCHEMBL8013224 | 0.80 | P2RX7 (1.00) | P2RX7KMT2A | |
| SCHEMBL3287222 | 0.80 | P2RX7 (1.00) | P2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049478-B1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | GLAXO GROUP LTD (GB) | 2012-05-30 | — | — | EP | disclosed |