Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | F9 | P00740 | 3/20 | 0.50 |
| ▸ | F11 | P03951 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233111 | 0.89 | F9 (0.65) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL1231149 | 0.89 | F9 (0.65) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL6918055 | 0.84 | F9 (0.63) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL9607759 | 0.82 | MEN1 (0.52) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL1231102 | 0.82 | ABCG2 (0.57) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL1232151 | 0.69 | F9 (0.62) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL6919971 | 0.69 | F9 (0.48) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL8095812 | 0.68 | ABCG2 (1.00) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL22201364 | 0.68 | ABCG2 (0.94) | MEN1KMT2AGBA1MAPTTP53 | |
| SCHEMBL9607749 | 0.67 | ABCG2 (0.50) | MEN1KMT2AGBA1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | F9, F8, F12 | MEN1 3347/4885KMT2A 2705/4885GBA1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.