Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 7/20 | 0.57 |
| ▸ | F11 | P03951 | 4/20 | 0.57 |
| ▸ | F10 | P00742 | 3/20 | 0.57 |
| ▸ | F7 | P08709 | 3/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514549 | 0.81 | F9 (0.58) | F9F11F10F7SMPD3 | |
| SCHEMBL1232343 | 0.79 | F10 (0.84) | F9F11F10F7CHEK2 | |
| SCHEMBL10140104 | 0.76 | NPBWR1 (0.36) | F9F11F10SMPD3CHEK2 | |
| SCHEMBL10140720 | 0.73 | PDPK1 (0.39) | SMPD3PDPK1CDK4CCNA2CCND1 | |
| SCHEMBL10140703 | 0.73 | CA12 (0.39) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL6918372 | 0.72 | F10 (1.00) | F9F11F10F7CHEK2 | |
| SCHEMBL10140767 | 0.70 | NPC1 (0.43) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL10140741 | 0.69 | KDM4E (0.42) | PDPK1KDM4ERAB9A | |
| SCHEMBL9607765 | 0.68 | F9 (0.44) | F9F11F10F7KDR | |
| SCHEMBL9607654 | 0.67 | F9 (0.39) | F9F11F10F7SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | F9, F8, F12 | F9 1/4885F11 5/4885F10 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.