Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.69 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.69 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.69 |
| ▸ | ABL2 | P42684 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 6/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | EPHA7 | Q15375 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15144984 | 0.92 | ABL1 (0.70) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL15499530 | 0.92 | ABL1 (0.70) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL10207524 | 0.90 | ABL1 (0.79) | ABL1NTRK3NTRK1NTRK2DDR1 | |
| SCHEMBL10207568 | 0.89 | ABL1 (0.79) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL15061738 | 0.85 | ABL1 (0.77) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL10265846 | 0.85 | ABL1 (0.68) | ABL1NTRK3NTRK1NTRK2DDR1 | |
| SCHEMBL15061730 | 0.82 | ABL1 (0.68) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL31474781 | 0.81 | ABL1 (0.78) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL21843620 | 0.81 | ABL1 (0.78) | ABL1NTRK3NTRK1NTRK2ABL2 | |
| SCHEMBL10207525 | 0.81 | ABL1 (0.65) | ABL1NTRK3NTRK1NTRK2ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029533-B2 | Substituted acetylenic imidazo[1,2-A]pyridazines as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20150105377-A1 | Methods and Compositions for RAF Kinase Mediated Diseases | ARIAD PHARMACEUTICALS, INC. | 2015-04-16 | — | — | US | disclosed |
| US-20130231337-A1 | Bicyclic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8470851-B2 | Substituted acetylenic imidazo[1,2-A]pyridine compounds as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120135986-A1 | Bicyclic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. (US) | 2012-05-31 | — | — | US | disclosed |
| US-8114874-B2 | Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20070191376-A1 | Bicyclic heteroaryl compounds | TAKEDA PHARMACEUTICALS U.S.A., INC. | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105377-A1 | Methods and Compositions for RAF Kinase Mediated Diseases | BRAF, RAF1, NRAS | ABL1 75/4885NTRK3 1546/4885NTRK1 1475/4885 |
| US-20070191376-A1 | Bicyclic heteroaryl compounds | CYP3A43, CYP11B2, CYP2F1 | ABL1 110/4885NTRK3 2458/4885NTRK1 3992/4885 |
| US-20130231337-A1 | Bicyclic Heteroaryl Compounds | CYP3A43, CYP11B2, CYP2F1 | ABL1 110/4885NTRK3 2458/4885NTRK1 3992/4885 |
| US-20120135986-A1 | Bicyclic Heteroaryl Compounds | CYP3A43, CYP11B2, CYP2F1 | ABL1 110/4885NTRK3 2458/4885NTRK1 3992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.