Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692489 | 0.93 | MAPK14 (0.45) | MAPK14HIF1AALDH1A1LMNACYP3A4 | |
| SCHEMBL692923 | 0.86 | FFAR1 (0.45) | MAPK14HIF1AMMP13MAPTMAPK11 | |
| SCHEMBL31591609 | 0.84 | KMT2A (0.49) | MAPK14ALDH1A1LMNACYP3A4HTT | |
| SCHEMBL690828 | 0.83 | SMN1; SMN2 (0.48) | ALDH1A1LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL9611041 | 0.82 | MAPK1 (0.57) | MAPK14MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL690195 | 0.79 | AKR1C2 (0.46) | MAPK14MAPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL691568 | 0.79 | RAB9A (0.47) | MAPK14MAPK1ALDH1A1LMNAHTT | |
| SCHEMBL12285316 | 0.78 | MECP2 (0.47) | MAPK14HIF1ALMNACYP3A4HTT | |
| SCHEMBL692348 | 0.77 | MEN1 (0.49) | MAPK14MAPK1 | |
| SCHEMBL692220 | 0.77 | HIF1A (0.47) | HIF1AALDH1A1SMN1; SMN2MAPTLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136003-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING 1,3,4-OXADIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136003-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING 1,3,4-OXADIAZOLE DERIVATIVES | CFTR, PKD1, PKD2 | MAPK14 3853/4885HIF1A 1855/4885MAPK1 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.