Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276911 | 0.91 | MAPT (0.44) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL15166977 | 0.80 | MAPT (0.38) | MAPTALDH1A1L3MBTL1NPSR1HTT | |
| SCHEMBL8950840 | 0.80 | SMN1; SMN2 (0.40) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL12905301 | 0.80 | MAPT (0.45) | MAPTALDH1A1L3MBTL1NPSR1HTT | |
| SCHEMBL12323501 | 0.80 | MAPT (0.45) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL14271660 | 0.79 | HTT (0.33) | MAPTHTT | |
| Hydrochloric Acid SCHEMBL9234685 | 0.77 | MAPT (0.43) | MAPTALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL16068213 | 0.77 | MAPT (0.44) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL9613093 | 0.77 | FFAR3 (0.40) | ALDH1A1CNR2HTT | |
| SCHEMBL8587408 | 0.77 | MAPT (0.34) | MAPTALDH1A1L3MBTL1NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021038426-A1 | SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-03-04 | — | — | WO | disclosed |
| EP-1727797-B1 | PROCESS FOR CROSS COUPLING INDOLES | BOEHRINGER INGELHEIM PHARMA (US) | 2012-05-30 | — | — | EP | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7332614-B2 | Process for cross coupling indoles | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2008-02-19 | — | — | US | disclosed |
| US-7332614-B2 | Process for cross coupling indoles | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2008-02-19 | — | — | US | disclosed |