Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.83 |
| ▸ | PTPN7 | P35236 | 15/20 | 0.78 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.78 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.71 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 5/20 | 0.65 |
| ▸ | BLM | P54132 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 3/20 | 0.65 |
| ▸ | RECQL | P46063 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | APEX1 | P27695 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613384 | 0.91 | IKBKB (1.00) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL6238251 | 0.88 | PTPN7 (1.00) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613318 | 0.84 | IKBKB (0.76) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613383 | 0.83 | PTPN7 (0.82) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613324 | 0.83 | PTPN7 (0.82) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613375 | 0.83 | PTPN7 (1.00) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613371 | 0.83 | IKBKB (0.85) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613373 | 0.83 | IKBKB (0.85) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613362 | 0.82 | PTPN7 (0.88) | IKBKBPTPN7KDM4DHSPD1HSPE1 | |
| SCHEMBL9613329 | 0.81 | PTPN7 (0.79) | IKBKBPTPN7KDM4DHSPD1HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353094-B2 | Substituted quinoxalines as kinase inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2015-10-01 | — | — | US | disclosed |
| US-8993758-B2 | Substituted quinoxalines and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2012071414-A2 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | IKBKB 11/4885PTPN7 1891/4885KDM4D 3685/4885 |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | IKBKB 11/4885PTPN7 1891/4885KDM4D 3685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.