Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11965521 | 0.75 | PHGDH (0.48) | PHGDHMGLLALDH1A1NPC1MEN1 | |
| SCHEMBL10807441 | 0.74 | ALDH1A1 (0.42) | PHGDHMGLLALDH1A1NPC1MEN1 | |
| SCHEMBL8476503 | 0.74 | — | — | |
| SCHEMBL22280596 | 0.74 | — | — | |
| SCHEMBL18635565 | 0.74 | — | — | |
| SCHEMBL9061263 | 0.73 | F2 (0.50) | PHGDHMGLLALDH1A1NPC1MEN1 | |
| SCHEMBL349335 | 0.73 | F2 (0.50) | PHGDHMGLLALDH1A1NPC1MEN1 | |
| SCHEMBL1336653 | 0.73 | ALDH1A1 (0.54) | PHGDHMGLLALDH1A1NPC1MEN1 | |
| SCHEMBL14603071 | 0.73 | PHGDH (0.58) | PHGDHMGLLALDH1A1NPC1MEN1 | |
| SCHEMBL12035253 | 0.73 | PHGDH (0.46) | PHGDHMGLLALDH1A1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071469-A2 | HISTONE DEMETHYLASE INHIBITORS AND USES THEREOF FOR TREATMENT O F CANCER | NEVADA CANCER INSTITUTE (US) | 2012-05-31 | — | — | WO | disclosed |