Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9613845 | 0.86 | KMT2A (0.50) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Oxalic Acid SCHEMBL9613942 | 0.86 | SLC6A4 (0.49) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Oxalic Acid SCHEMBL9614126 | 0.85 | KMT2A (0.49) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Oxalic Acid SCHEMBL9613944 | 0.84 | KMT2A (0.48) | KMT2AKDM4EALDH1A1HPGDATM | |
| Oxalic Acid SCHEMBL9613860 | 0.83 | KMT2A (0.48) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Dapoxetine SCHEMBL9614075 | 0.82 | KMT2A (0.59) | KMT2AKDM4EALDH1A1HPGDATM | |
| Oxalic Acid SCHEMBL9613984 | 0.81 | KMT2A (0.52) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Oxalic Acid SCHEMBL9613810 | 0.78 | KMT2A (0.52) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Oxalic Acid SCHEMBL9613796 | 0.78 | KMT2A (0.51) | SLC6A4KMT2AKDM4EALDH1A1HPGD | |
| Oxalic Acid SCHEMBL9613788 | 0.78 | CHRNB2 (0.48) | KMT2AKDM4EALDH1A1MCL1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |