Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9614269 | 0.90 | PPARA (0.51) | PPARAPPARGMMP2MMP9S1PR2 | |
| SCHEMBL9614023 | 0.89 | PPARA (0.47) | PPARAPPARGMMP2MMP9HDAC3 | |
| SCHEMBL10420482 | 0.89 | PPARA (0.47) | PPARAPPARGMMP2MMP9HDAC3 | |
| SCHEMBL9613995 | 0.89 | PPARA (0.53) | PPARAPPARGMMP2MMP9S1PR2 | |
| SCHEMBL10420435 | 0.87 | PPARA (0.48) | PPARAPPARGMMP2MMP9HDAC3 | |
| SCHEMBL9613829 | 0.86 | KMT2A (0.45) | PPARAPPARGMMP2MMP9HDAC3 | |
| SCHEMBL9614107 | 0.85 | PPARA (0.48) | PPARAPPARGMMP2MMP9HDAC3 | |
| SCHEMBL9614046 | 0.85 | PPARA (0.48) | PPARAPPARGMMP2MMP9TBXAS1 | |
| SCHEMBL9614112 | 0.85 | PPARA (0.48) | PPARAPPARGMMP2MMP9HDAC3 | |
| SCHEMBL9858450 | 0.85 | PPARA (0.48) | PPARAPPARGMMP2MMP9HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145611-A | Diabetes | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-08 | — | — | US | disclosed |
| EP-0279162-B1 | CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1991-06-19 | — | — | EP | disclosed |
| EP-0279162-A1 | Carbonic acid derivatives, process for their preparation and pharmaceuticals containing them | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |