Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 4/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604032 | 0.88 | IDO1 (0.52) | IDO1GPR84KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL12604015 | 0.83 | IDO1 (0.50) | CYP1A2IDO1GPR84KDM4ESMN1; SMN2 | |
| SCHEMBL25638485 | 0.83 | CNR1 (0.51) | CYP1A2IDO1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL16065361 | 0.81 | CYP1A2 (0.48) | CYP1A2IDO1GPR84KDM4ESMN1; SMN2 | |
| SCHEMBL14396287 | 0.81 | IDO1 (0.66) | CYP1A2IDO1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL12460239 | 0.81 | CNR1 (0.52) | CYP1A2IDO1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6715331 | 0.79 | CNR1 (0.55) | CYP1A2MEN1KMT2ALMNATDP1 | |
| SCHEMBL18949728 | 0.79 | HTR1B (0.63) | CYP1A2KDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8229480 | 0.79 | CYP1A2 (0.54) | CYP1A2KDM4ESMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2023982 | 0.78 | IDO1 (0.71) | IDO1GPR84KDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| EP-0288188-A1 | 1-Phenyl-3-naphthalenyloxy-propanamines | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |