Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 7/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613948 | 0.86 | HTR1B (0.45) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9613953 | 0.86 | MCL1 (0.47) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9613784 | 0.84 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9613811 | 0.83 | KDM4E (0.50) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9613852 | 0.82 | HTR1B (0.46) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9614037 | 0.79 | HTR1B (0.45) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9614067 | 0.77 | MCL1 (0.48) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9613906 | 0.77 | MCL1 (0.44) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9614132 | 0.74 | HTR1B (0.47) | ALDH1A1HPGDKDM4EHTR1BTDP1 | |
| SCHEMBL9613949 | 0.72 | HTR1B (0.45) | ALDH1A1HPGDKDM4EHTR1BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |