Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103998 | 0.91 | THRB (0.59) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL9507918 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL21110886 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL29424252 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL9515791 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL8576260 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL16237412 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL9507657 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL31011413 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL10562779 | 0.89 | THRB (0.58) | THRBMAPTL3MBTL1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4117386-A | — | — | None | — | — | JP | disclosed |
| JP-H04117386-A | PHOTOCHROMIC COMPOUND | CITIZEN WATCH CO LTD | 1992-04-17 | — | — | JP | disclosed |