Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.95 |
| ▸ | CES2 | O00748 | 1/20 | 0.64 |
| ▸ | CES1 | P23141 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55127 | 0.98 | — | — | |
| SCHEMBL29358072 | 0.98 | — | — | |
| Methyl Alcohol SCHEMBL27687010 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| SCHEMBL27414956 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| SCHEMBL30311517 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| Hydrogen Sulfide SCHEMBL27781949 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| Hydrochloric Acid SCHEMBL7049723 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| Hydrochloric Acid SCHEMBL27718978 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| Hydrochloric Acid SCHEMBL11271158 | 0.93 | ALDH1A1 (0.91) | ALDH1A1CES2CES1L3MBTL1LMNA | |
| Hydrazine SCHEMBL6056730 | 0.93 | ALDH1A1 (0.91) | ALDH1A1CES2CES1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4066291-A | — | — | None | — | — | JP | disclosed |
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |
| JP-H0466291-A | CREAM SOLDER FOR PRINTING | UCHIHASHI ESTEC CO LTD | 1992-03-02 | — | — | JP | disclosed |