Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 12/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL961783 | 1.00 | PRKD1 (0.60) | PRKD1PRKD3PRKD2WDR5NPC1 | |
| SCHEMBL959487 | 0.88 | PRKD1 (0.76) | PRKD1PRKD3PRKD2LIMK1 | |
| SCHEMBL959488 | 0.88 | PRKD1 (0.76) | PRKD1PRKD3PRKD2LIMK1 | |
| SCHEMBL935479 | 0.87 | PRKD1 (0.79) | PRKD1PRKD3PRKD2WDR5NPC1 | |
| SCHEMBL6923549 | 0.84 | PRKD1 (0.54) | PRKD1WDR5NPC1ALDH1A1RAB9A | |
| SCHEMBL6923773 | 0.82 | PRKD1 (0.78) | PRKD1PRKD3PRKD2WDR5CXCR1 | |
| SCHEMBL958900 | 0.79 | PRKD1 (0.77) | PRKD1PRKD3PRKD2ALDH1A1 | |
| SCHEMBL935776 | 0.79 | PRKD1 (0.59) | PRKD1NPC1ALDH1A1RAB9A | |
| SCHEMBL957994 | 0.78 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ALDH1A1 | |
| SCHEMBL6922372 | 0.78 | PRKD1 (0.70) | PRKD1PRKD3PRKD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |