SCHEMBL9619397

SCHEMBL9619397

CC1C(CO)OC1(Cn1cncn1)c1ccc(Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.41
THRB P10828 1/20 0.41
ALDH1A1 P00352 2/20 0.40
HSP90AA1 P07900 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CYP2C9 P11712 2/20 0.38
KDM4E B2RXH2 2/20 0.38
HTT P42858 2/20 0.38
POLB P06746 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 3/20 0.37
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.35
MC4R P32245 2/20 0.35
MC3R P41968 1/20 0.34
MC1R Q01726 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9619400 1.00 CYP3A4 (0.41) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9735927 0.89 CYP3A4 (0.47) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9735922 0.89 CYP3A4 (0.47) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9199001 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9843779 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9735464 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9736709 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9199815 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9741267 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1
SCHEMBL9198999 0.85 CYP3A4 (0.44) CYP3A4THRBALDH1A1HSP90AA1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4368383-A None JP disclosed
JP-H04368383-A 4-SUBSTITUTED OXETANE DERIVATIVE SANKYO CO LTD 1992-12-21 JP disclosed