SCHEMBL9619404

SCHEMBL9619404

CCOC(=O)c1c(-c2ccccc2)c(C#N)c(=O)n2ccccc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 12/20 0.55
NPSR1 Q6W5P4 3/20 0.55
RXFP1 Q9HBX9 2/20 0.55
HTT P42858 1/20 0.55
CYP1A2 P05177 3/20 0.55
CYP3A4 P08684 2/20 0.55
IDO1 P14902 2/20 0.55
MAPK1 P28482 2/20 0.55
HBB P68871 1/20 0.55
HIF1A Q16665 1/20 0.55
L3MBTL1 Q9Y468 2/20 0.53
KDM4E B2RXH2 9/20 0.52
HPGD P15428 5/20 0.52
GAA P10253 3/20 0.51
GLA P06280 1/20 0.51
TSHR P16473 1/20 0.50
KMT2A Q03164 4/20 0.49
MEN1 O00255 3/20 0.49
CYP2C9 P11712 2/20 0.49
CYP2C19 P33261 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9619644 0.98 ALDH1A1 (0.53) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619356 0.94 ALDH1A1 (0.53) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619355 0.93 ALDH1A1 (0.52) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619336 0.92 ALDH1A1 (0.49) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619627 0.92 ALDH1A1 (0.53) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619432 0.92 ALDH1A1 (0.56) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619365 0.92 ALDH1A1 (0.51) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619357 0.91 ALDH1A1 (0.46) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619574 0.91 ALDH1A1 (0.56) ALDH1A1NPSR1RXFP1HTTCYP1A2
SCHEMBL9619449 0.91 ALDH1A1 (0.50) ALDH1A1NPSR1RXFP1HTTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0309260-B1 4H-QUINOLIZIN-4-ONE COMPOUNDS EXHIBITING THERAPEUTIC ACTIVITIES Kissei Pharmaceutical Co., Ltd. (JP) 1992-01-15 EP claimed
US-4904657-A 4H-quinolizin-4-one compounds exhibiting therapeutic activities KISSEI PHARMACEUTICAL CO., LTD. (JP) 1990-02-27 US claimed
JP-1083080-A None JP disclosed
EP-0309260-B1 4H-QUINOLIZIN-4-ONE COMPOUNDS EXHIBITING THERAPEUTIC ACTIVITIES Kissei Pharmaceutical Co., Ltd. (JP) 1992-01-15 EP disclosed
US-4904657-A 4H-quinolizin-4-one compounds exhibiting therapeutic activities KISSEI PHARMACEUTICAL CO., LTD. (JP) 1990-02-27 US disclosed
EP-0309260-A1 4H-Quinolizin-4-one compounds exhibiting therapeutic activities Kissei Pharmaceutical Co., Ltd. (JP) 1989-03-29 EP disclosed