Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262666 | 0.88 | CYP1A2 (0.46) | HTTMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL4823046 | 0.83 | CALM1 (0.57) | HTTMEN1KMT2AALDH1A1ACHE | |
| SCHEMBL18546022 | 0.82 | HTT (0.69) | HTTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL122771 | 0.82 | HTT (0.68) | HTTMEN1KMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL6162321 | 0.80 | HTT (0.66) | HTTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9641405 | 0.79 | HTT (0.69) | HTTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL79747 | 0.78 | HTT (0.62) | HTTMEN1KMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2313460 | 0.77 | HTT (0.61) | HTTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9320386 | 0.77 | HTT (0.66) | HTTMEN1KMT2AALDH1A1LMNA | |
| Bromide SCHEMBL15391224 | 0.77 | HTT (0.61) | HTTMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280227-B1 | N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE COMPOUNDS AS AGENTS FOR TREATING DISORDERS OF CARDIOVASCULAR SYSTEM | SUNTORY LIMITED (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4920124-A | HYPOTENSIVE AND CARDIOTONIC AGENTS; VASODILATION | SUNTORY LIMITED (JP) | 1990-04-24 | — | — | US | disclosed |
| EP-0280227-A1 | N-substituted 3,4-dihydropyrimidine compounds as agents for treating disorders of cardiovascular system | SUNTORY LIMITED (JP) | 1988-08-31 | — | — | EP | disclosed |