Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15749699 | 0.87 | MEN1 (0.76) | KMT2AMEN1DCTPP1ADORA1GAA | |
| SCHEMBL10811515 | 0.85 | KMT2A (0.74) | KMT2AMEN1DCTPP1ADORA1GAA | |
| SCHEMBL15749761 | 0.83 | MEN1 (0.71) | KMT2AMEN1DCTPP1ADORA1GAA | |
| SCHEMBL15749749 | 0.80 | DCTPP1 (0.76) | KMT2AMEN1DCTPP1ADORA1GAA | |
| SCHEMBL15749589 | 0.79 | DCTPP1 (0.78) | KMT2AMEN1DCTPP1ADORA1GAA | |
| SCHEMBL10309248 | 0.79 | MEN1 (0.65) | KMT2AMEN1ADORA1GAAMAPK1 | |
| SCHEMBL23297559 | 0.77 | MEN1 (0.63) | KMT2AMEN1DCTPP1GAAMAPT | |
| SCHEMBL9122257 | 0.77 | ADORA1 (1.00) | KMT2AMEN1ADORA1ADORA2AADORA2B | |
| SCHEMBL13977083 | 0.77 | DCTPP1 (1.00) | KMT2AMEN1DCTPP1ADORA1GAA | |
| SCHEMBL15749659 | 0.77 | DCTPP1 (0.75) | KMT2AMEN1DCTPP1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271192-B1 | PURINE HISTAMINE H1 ANTAGONISTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0271192-A2 | Purine histamine H1 antagonists, their preparation and pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4716166-A | PURINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-12-29 | — | — | US | disclosed |