Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.51 |
| ▸ | MAOB | P27338 | 8/20 | 0.49 |
| ▸ | MAOA | P21397 | 7/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781925 | 0.92 | MAOB (0.53) | HRH3MAOBMAOAALOX5CYP2D6 | |
| SCHEMBL9621104 | 0.78 | SLC2A1 (0.40) | MAOBMAOACYP2D6 | |
| SCHEMBL7795457 | 0.77 | MAOB (0.52) | HRH3MAOBMAOAALOX5CYP2D6 | |
| SCHEMBL9621003 | 0.77 | MEN1 (0.38) | HRH3 | |
| SCHEMBL18839037 | 0.75 | HRH3 (0.52) | HRH3MAOBMAOAALOX5CYP2D6 | |
| SCHEMBL9620717 | 0.75 | HRH3 (0.37) | HRH3MAOBMAOA | |
| SCHEMBL225661 | 0.74 | MAOB (0.51) | HRH3MAOBMAOAALOX5CYP2D6 | |
| SCHEMBL30616511 | 0.74 | MAOB (0.51) | HRH3MAOBMAOAALOX5CYP2D6 | |
| SCHEMBL11519620 | 0.74 | HRH3 (0.55) | HRH3MAOBMAOAALOX5CYP2D6 | |
| SCHEMBL9621156 | 0.74 | MAOB (0.35) | HRH3MAOBMAOACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| EP-0368670-A1 | Trisubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-05-16 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| CN-88101588-A | Preparation 1, the method for 4-disubstituted piperazines compounds | — | 1988-11-23 | — | — | CN | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |