SCHEMBL7795457

SCHEMBL7795457

[C]1=Cc2cc(OCc3ccccc3)ccc2C1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.52
MAOA P21397 6/20 0.52
HRH3 Q9Y5N1 6/20 0.50
ALOX5 P09917 1/20 0.50
CYP3A4 P08684 1/20 0.46
CA2 P00918 1/20 0.45
CA5A P35218 1/20 0.45
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
PTGS1 P23219 1/20 0.45
SLC6A2 P23975 1/20 0.45
CYP2C19 P33261 1/20 0.45
PTGS2 P35354 1/20 0.45
SLC6A3 Q01959 1/20 0.45
HIF1A Q16665 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
CYP2D6 P10635 2/20 0.44
KDM1A O60341 1/20 0.44
HRH1 P35367 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9620868 0.77 HRH3 (0.51) MAOBMAOAHRH3ALOX5CYP2D6
SCHEMBL9781925 0.74 MAOB (0.53) MAOBMAOAHRH3ALOX5CA2
SCHEMBL15069704 0.74 ALOX5 (0.51) MAOBMAOAHRH3ALOX5CA2
SCHEMBL9492783 0.72 ALOX5 (0.61) MAOBMAOAALOX5CA2CA5A
SCHEMBL28316590 0.72 HRH3 (0.52) MAOBMAOAHRH3ALOX5CA2
SCHEMBL30299191 0.71 HRH3 (0.72) MAOBMAOAHRH3CYP2D6KDM1A
SCHEMBL12472442 0.71 HRH3 (0.72) MAOBMAOAHRH3LMNACYP2D6
SCHEMBL9164095 0.71 MAOA (0.51) MAOBMAOAHRH3ALOX5CA2
SCHEMBL8762323 0.70 HRH3 (0.57) MAOBMAOAHRH3ALOX5CYP2D6
SCHEMBL339813 0.70 LMNA (0.82) MAOBMAOAALOX5CA2CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070703-A1 Cyclobutene derivatives Sankyo Company Limited (JP) 2001-01-24 EP disclosed