Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620917 | 0.94 | POLB (0.54) | POLBLMNAMAPTNPSR1KMT2A | |
| SCHEMBL9620850 | 0.93 | KMT2A (0.53) | POLBLMNAMAPTKMT2AGAA | |
| SCHEMBL9621368 | 0.92 | SMN1; SMN2 (0.58) | POLBLMNAMAPTNPSR1KMT2A | |
| SCHEMBL9620863 | 0.92 | POLB (0.58) | POLBLMNANPSR1GAASMN1; SMN2 | |
| Methyl Alcohol SCHEMBL9782201 | 0.91 | POLB (0.57) | POLBLMNAGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL9620811 | 0.90 | POLB (0.58) | POLBLMNANPSR1GAASMN1; SMN2 | |
| SCHEMBL9620806 | 0.90 | POLB (0.58) | POLBLMNANPSR1GAASMN1; SMN2 | |
| SCHEMBL9621351 | 0.89 | KDM4E (0.48) | POLBLMNAMAPTNPSR1KMT2A | |
| Hydrochloric Acid SCHEMBL9620725 | 0.88 | KDM4E (0.48) | POLBLMNAMAPTNPSR1KMT2A | |
| SCHEMBL9621378 | 0.87 | ALDH1A1 (0.53) | POLBLMNASMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |