Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936909 | 0.88 | PPARG (0.43) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL10691810 | 0.84 | CYSLTR2 (0.63) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL10691645 | 0.84 | PPARG (0.53) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11047621 | 0.83 | PPARG (0.46) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL4343526 | 0.82 | PPARG (0.67) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL3958076 | 0.81 | MAPT (0.49) | PPARGPPARDPPARALMNAMAPT | |
| SCHEMBL10920716 | 0.80 | CYSLTR2 (0.50) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL9777348 | 0.80 | PPARG (0.42) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL10921520 | 0.79 | CYSLTR2 (0.48) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL10925330 | 0.79 | CYSLTR2 (0.48) | PPARGPPARDPPARALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232820-B1 | THIOETHERS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1992-01-08 | — | — | EP | disclosed |
| US-5025028-A | Asthma | BOEHRINGER MANNHEIM GMBH (DE) | 1991-06-18 | — | — | US | disclosed |
| US-4906666-A | Hydroxamic acids and pharmaceutical compositions containing them, and anti-allergic use thereof | BOEHRINGER MANNHEIM GMBH (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0232820-A2 | Thioethers, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1987-08-19 | — | — | EP | disclosed |
| US-4621098-A | Thioethers and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1986-11-04 | — | — | US | disclosed |