Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Diamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | THPO | P40225 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | APEX1 | P27695 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15358882 | 0.92 | ALDH1A1 (0.68) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL13680778 | 0.85 | TSHR (1.00) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL39340 | 0.85 | TSHR (1.00) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL103289 | 0.85 | TSHR (1.00) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| SCHEMBL293386 | 0.83 | ALDH1A1 (0.72) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| SCHEMBL11800451 | 0.83 | ALDH1A1 (0.72) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL1681704 | 0.82 | TSHR (0.93) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL8186446 | 0.82 | TSHR (0.93) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL1772314 | 0.82 | TSHR (0.93) | ALDH1A1HSD17B10TSHRPMP22NFKB1 | |
| Diamide SCHEMBL29975194 | 0.82 | TSHR (0.93) | ALDH1A1HSD17B10TSHRPMP22NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201340-B1 | TONER COMPOSITION AND METHOD FOR PREPARING THE SAME | Kao Corporation (JP) | 1992-04-01 | — | — | EP | disclosed |
| US-4749638-A | CARBON BLACK, DISPERSANT, POLYMERIC BINDER OIL PHASE EMULSION POLYMERIZATION | KAO CORPORATION (JP) | 1988-06-07 | — | — | US | disclosed |
| EP-0201340-A2 | Toner composition and method for preparing the same | Kao Corporation (JP) | 1986-11-12 | — | — | EP | disclosed |