Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670725 | 0.89 | CRBN (0.43) | GAACRBNKMT2APOLBDDB1 | |
| SCHEMBL9621564 | 0.89 | CRBN (0.40) | GAACRBNKMT2APOLBALDH1A1 | |
| SCHEMBL9820818 | 0.87 | GBA1 (0.41) | CRBNKMT2APOLBALDH1A1LMNA | |
| SCHEMBL9670978 | 0.87 | GBA1 (0.41) | CRBNKMT2APOLBALDH1A1LMNA | |
| SCHEMBL9820839 | 0.87 | GBA1 (0.41) | CRBNKMT2APOLBALDH1A1LMNA | |
| SCHEMBL9820748 | 0.87 | GBA1 (0.41) | CRBNKMT2APOLBALDH1A1LMNA | |
| SCHEMBL9820784 | 0.87 | GBA1 (0.41) | CRBNKMT2APOLBALDH1A1LMNA | |
| SCHEMBL525863 | 0.84 | — | — | |
| SCHEMBL28125389 | 0.84 | — | — | |
| SCHEMBL9821225 | 0.80 | MAPT (0.34) | KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239500-A2 | 1-Styrene-sulfonyl-2-oxo-5-hydroxy-pyrrolidine derivatives, their intermediates, process for their preparation, compositions containing them and their use as medicines | ROUSSEL-UCLAF (FR) | 1987-09-30 | — | — | EP | claimed |
| EP-0229566-B1 | 1-BENZENE SULFONYL 2-OXO-5-ALKOXY PYRROLIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINE AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | disclosed |
| EP-0239500-B1 | 1-STYRENE-SULFONYL-2-OXO-5-HYDROXY-PYRROLIDINE DERIVATIVES, THEIR INTERMEDIATES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | disclosed |
| EP-0296979-B1 | 1-BENZOYL-2-OXO-5-ALKOXY-PYRROLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PREPARATIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-12-04 | — | — | EP | disclosed |
| EP-0296978-B1 | 1-BENZYL 2-OXO 5-ALKOXY PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINES | ROUSSEL-UCLAF (FR) | 1991-09-11 | — | — | EP | disclosed |
| US-4948804-A | TREATING PSYCHOLOGICAL DISORDERS | ROUSSEL UCLAF (FR) | 1990-08-14 | — | — | US | disclosed |
| US-4882350-A | TREATMENT OF INTELLECTUAL OR NERVOUS ASTHENIAS, MEMORY FAILURES | ROUSSEL UCLAF (FR) | 1989-11-21 | — | — | US | disclosed |
| US-4829079-A | AMNESIA | ROUSSEL UCLAF (FR) | 1989-05-09 | — | — | US | disclosed |
| US-4810722-A | COGNITION ACTIVATORS | ROUSSEL UCLAF (FR) | 1989-03-07 | — | — | US | disclosed |
| EP-0296978-A2 | 1-Benzyl 2-oxo 5-alkoxy pyrrolidine derivatives, process for their preparation, compositions containing them and their use in medicines | ROUSSEL-UCLAF (FR) | 1988-12-28 | — | — | EP | disclosed |
| EP-0296979-A2 | 1-Benzoyl-2-oxo-5-alkoxy-pyrrolidine derivatives, their preparation, their use and preparations containing them | ROUSSEL-UCLAF (FR) | 1988-12-28 | — | — | EP | disclosed |
| EP-0239500-A2 | 1-Styrene-sulfonyl-2-oxo-5-hydroxy-pyrrolidine derivatives, their intermediates, process for their preparation, compositions containing them and their use as medicines | ROUSSEL-UCLAF (FR) | 1987-09-30 | — | — | EP | disclosed |
| EP-0229566-A2 | 1-Benzene sulfonyl 2-oxo-5-alkoxy pyrrolidines, process for their preparation, their use as medicine and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-07-22 | — | — | EP | disclosed |