SCHEMBL9621766

SCHEMBL9621766

C[Si](C)(C)Nc1cccc(N)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
GAA P10253 2/20 0.52
KMT2A Q03164 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
KDM4E B2RXH2 1/20 0.52
LMNA P02545 1/20 0.52
MAPT P10636 1/20 0.52
GFER P55789 1/20 0.52
ALDH1A1 P00352 5/20 0.50
DDX3X O00571 2/20 0.48
RAPGEF4 Q8WZA2 1/20 0.47
CYP3A4 P08684 2/20 0.46
CASP1 P29466 1/20 0.46
RECQL P46063 1/20 0.46
HTR6 P50406 2/20 0.42
NR4A1 P22736 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SYK P43405 1/20 0.40
AHR P35869 1/20 0.40
MAP4K4 O95819 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11147093 0.84 MAPT (0.42) MEN1KMT2ATDP1KDM4EMAPT
SCHEMBL9060568 0.78 MEN1 (0.47) MEN1GAAKMT2ATDP1KDM4E
SCHEMBL30013886 0.75
SCHEMBL1488513 0.75
SCHEMBL28049256 0.74 CYP3A4 (0.52) MEN1KMT2ALMNAMAPTGFER
SCHEMBL2127990 0.74 MAPT (0.86) MEN1GAAKMT2ATDP1KDM4E
SCHEMBL2141808 0.74
Hydrochloric Acid SCHEMBL21647359 0.72 MAPT (0.82) MEN1GAAKMT2ATDP1KDM4E
SCHEMBL27491108 0.72 RAD52 (0.44) MEN1KMT2ATDP1KDM4ELMNA
Hydrochloric Acid SCHEMBL31528395 0.72 MAPT (0.82) MEN1GAAKMT2ATDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5128429-A Low temperature block polymerization without randomization RAYCHEM LIMITED (GB) 1992-07-07 US disclosed
EP-0154506-B1 PREPARATION OF ORGANIC POLYMERS RAYCHEM LIMITED (GB) 1992-02-05 EP disclosed
US-4999411-A Polythioethers, polythiocarbonates, polythioamides, polythioimides RAYCHEM LIMITED (GB) 1991-03-12 US disclosed
US-4960835-A ENGINEERING THERMOPLASTICS RAYCHEM LIMITED (GB) 1990-10-02 US disclosed
US-4845179-A CONDENSATION POLYMERIZATION RAYCHEM LIMITED (GB) 1989-07-04 US disclosed
EP-0154506-A2 Preparation of organic polymers RAYCHEM LIMITED (GB) 1985-09-11 EP disclosed